Trimethoprim: Uses, Interactions, Mechanism of Action by- The Medicine Library

Trimethoprim:

Taruf:

Trimethoprim ek aam taur par istemaal hone wali anti-biotic hai jiska taluq diaminopyrimidine antimicrobial agents ki class se hai. Yeh mukhtalif bacterial infections ke ilaj ke liye istemaal hota hai, jaise peshab ki naali ke infection, sans ki naali ke infection, aur jild aur naram tissue ke infection. Yahan trimethoprim ke amal ke tareeqay kaar, pharmacokinetics, spectrum, istemaal, manfi asraat, aur tazadat ka tafseeli jayeza hai.

Amal ka tareeqa kaar:

Trimethoprim bacterial enzyme dihydrofolate reductase ko rok kar kaam karta hai, jo ke tetrahydrofolic acid ki tarteeb mein shaamil hai, jo ke bacteria mein nucleic acids (DNA aur RNA) ki tarteeb ka aik lazmi paish-e-khidmat hai. Dihydrofolate reductase ko rok kar, trimethoprim nucleic acid ki paidawar ko rokta hai, jis se bacteria ki nashonuma aur naqal ki rok tham hoti hai.

DAWA sazi:

Trimethoprim zubani intizamiya ke baad achi tarah jazb ho jata hai, plasma mein 1 se 4 ghante ke andar andar sab se zyada irtikaaz hota hai. Yeh poore jism mein bade paimane par taqseem hota hai aur sozish ki mojoodgi mein CSF (dimaagi spinal siyal) mein dakhil hosakta hai. Trimethoprim jigar mein metabolize hota hai aur peshab mein kharij hota hai, taqreeban 8 se 10 ghante ki nisf zindagi ke saath.

Spectrum:

Trimethoprim grame-positive aur grame-negative dono bacteria ke khilaf sargarmi ka ek wasee field hai, beshumar bacteria jaise Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, aur Staphylococcus aureus iske khilaf sensitive hote hain. Yeh aksar sulfamethoxazole ke saath mil kar istemaal hota hai, jismein ek jaisa tareeqa kar aur sargarmi ke wasee field hote hain.

Istemaal karta hai:

Trimethoprim aam tor par mukhtalif bacterial infections ke ilaj ke liye istemaal kiya jata hai, beshumar infections mein se kuchh shamil hain:

Peshab ki naali ke infection (UTIs):

 Trimethoprim aksar sensitive bacteria ki wajah se UTIs ke ilaj ke liye istemaal hota hai.

Saans ki naali ke infection: Trimethoprim saans ki naali ke kuchh infections ke khilaf mufeed hai, jaise ki daimi bronchitis aur pneumonia ki wajah se jo sensitive bacteria ki wajah se hota hai.

Jild aur naram bafton ke infection:

 Trimethoprim baaz auqat sensitive bacteria ki wajah se jild aur naram bafton ke infection ke ilaj ke liye istemaal kiya jata hai.

Bora asarath:

"Trimethoprim" aam tor par achi tarah se bardasht kiya jata hai, lekin kuch manfi asraat ho sakte hain, jin mein shamil hain:

Maida (GI) mein khallal: 

Trimethoprim ke sab se aam manfi asraat mein matli, ultee aur ishaal shamil hain.

Dadorah:

 Trimethoprim jild par khushki ya degar allergy ki taraf muntaqil ho sakta hai, jaise chhate ya khushki.

Hematological (khoon ki) asraat:

 Shadeed aur nadir haalat mein, Trimethoprim haddiyon ke guday ko dabane ka sabab ban sakta hai, jis se khoon ki kami, leukopenia ya thrombocytopenia ho sakti hai.

Tazadat:

Trimethoprim manshiyat ya degar diaminopyrimidines ke liye intehai hasasit ki tareekh wale afraad mein mutazad hai. Hamila aur doodh pilane wali khawateen ke sath sath jigar ya gurday ki shadeed bemari wale afraad mein bhi is se bachna chahiye.

Nateeja:

"Trimethoprim" aik aam tor par istemaal honey wali anti-biotic hai, jo bacterial enzyme "dihydrofolate reductase" ko rok kar kaam karta hai. Is mein gram musbat aur gram manfi donon bacteria ke khilaf sargarmi ka aik wasee medaan hai aur yeh aam tor par peshab ki nali ke infection, sans ki nali ke infection, aur jild aur naram bafoton ke infection ke ilaj ke liye istemaal hota hai. Manfi asraat ho sakte hain, lekin wo aam tor par achi tarah se bardasht kar rahe hain. "Trimethoprim" ko kuch abadiyon mein ehtiyaat ke sath istemaal kiya jana chahiye, jaise hamila ya doodh pilane wali khawateen, aur jin ko jigar ya gurday ki shadeed bemari hai.