Rifampin:
Taruf:
Yeh Tap Daq ke ilaj ke liye istemaal honay wali pehli line anti-tubercular dawa hai. Rifampin, rifabutin aur rifapentin sabhi ko rifamycin samjha jata hai, jo saakhti tor par milte julte micro-cyclic anti-biotic ka ek group hai. Yeh selective hain aur insanee RNA polymerase se mansalik nahin ho saktay. Bunyadi tor par iska istemaal bacterial infections jaisey Tap Daq ke ilaj ke liye kya jata hai, jo AYUM complex aur Legionnaires ki bemari ke liye bhi istemaal hota hai. Rifampin jaraasim kash sargarmi dekhata hai.
Formula:
Rifampin ka formula C₄₃H₅₈N₄O₁₂ hai.
Tijarti naam:
Is ka tijarti naam Rifadin hai.
Amal ka tareeqa kar:
Yeh bunyadi tor par Mycobacterial DNA par munhasar RNA polymerase ke beta subunit ke sath bat cheet kar ke mRNA nqal ko rokta hai.
Dawasazi:
Rifampin zubani tor par achi tarah jazb hoti hai aur jism mein achi taqseem hoti hai. Yeh CSF mein dakhool kam hai. Yeh jigar aur aanton ki deewar mein metabolize hota hai. Yeh phore, granuloma aur microphages mein ghus jata hai. Rifampin mein achi plasma protein binding hoti hai aur peshab ke zariye kharij hoti hai.
Ye bunyadi tor par T.B ki treatment mein istemal kiya jata hai (faail tap daq ke liye 600mg/day jabkay oweekat 600mg haftey mein do baar). Ye juzam aur Ayeveaim complex ke liye bhi istemal hota hai. Rifampin ke dosray istemal mein Endocarditis, Osteomyelitis, bachon mein Type B influenza ko rokna aur Meningococcal carrier ko khatam karna hai.
Muzahimat:
Jab DNA par mohnasib RNA polymerase ki wabastagi mein tabdeeli hoti hai to ye muzahimat zahir karta hai. Agar tanha istemal kya jaye to is ney muzahimat bhi tayyar ki.
Spectrum:
Rifampin gram musbat aur gram manfi kokki, klimidia, mycobacteria aur enterobacteria ke khilaf sargarmi rakhti hai.
Manfi asar:
Rifampin jism ko narangi rang dene ka sabab ban sakta hai. Is mein flu jaisey syndrome (bukhar, sardi lagna, khoon ki kami) hai. Ye thrombocytopenia, cholestatic yaqeen aur hepatitis ka sabab bhi ban sakta hai.
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