Rimantadine Ora-Uses, Side Effects-Interactions..by-The Medicine Library

 Rimantadine:

Tarruf:

Rimantadine aik anti-viral dawa hai jise 1994 mein American Food and Drug Administration (FDA) ne balghon mein influenza A virus ke infection ke ilaj aur rok tham ke liye istemaal karne ki manzoori di thi. Is ka talluq Admantadine ke khandaan se hai aur sakhti tor par ek aur anti-viral dawai Amantadine se milta julta hai. Rimantadine influenza virus ke un coat ko kaatnay ke amal mein madad karkay apna anti-viral asar daalta hai, is tarah virus ki naqal ko rokta hai. Is article mein, hum amal ke tareeqay kaar, pharmacokinetics, sargarmi ke spectrum, tibbi istemaal, manfi asrat, tazadat, aur Rimantadine ke manshiyat ke talluq par tabadla-e-khayal karenge.

Amal ka tareeqa kaar:

Rimantadine M2 protein ke saath mudakhlat karke Influenza A virus ke in cutting ke amal ko rokta hai, jo ke virus ke liye zaroori hai ke wo apne genetic material ko mehazban khalie mein khole aur kharij kare. Khas tor par, Rimantadine M2 protein ke zariye banne wale ion channel ko rokta hai, jo virus ke zarah ki taizabiyyat aur iske genetic material ke akhraj ke liye zaroori hai. Iss amal ko rok kar, Rimantadine virus ki nafal aur infection ke phailao ko rokta hai.

Duasazi:

Zabani intizamiyah ke baad Rimanatadeen maaday ki naali se taizi se jazb ho jati hai, plasma mein 2 se 5 ghanton ke andar andar aala tareen irtikaz hasil hota hai. Dawa jigar mein baray paimanay par metabolize hoti hai, buniyadi tor par CYP2C9 aur CYP3A4 enzymes ke zariye, aur is ke metabolites peshab mein kharij hotay hain. Rimanatadeen ki nisf zindagi taqreeban 24-36 ghanton hai, aur dawa 3-7 dino ke andar jism se kharij ho jati hai.

Sargarmi ka daireh:

Rimanatadeen influenza A virus ke khilaf sargarm hai, lekin influenza B virus ke khilaf nahi. Yeh degar sans ke viruses ke khilaf bhi karguzar nahi hai, jaise ke sans ki syncytial virus (RSV) ya adenovirus.

Tibbi istemaal:

Rimantadine balghon mein influenza A virus ke infection ke ilaj aur prophylaxis ke liye istemaal kiya jata hai. Yeh alamat ke shuru hone ke 48 ghanton ke andar istemaal karne ki sifarish ki jati hai aur jab infection ke shuru mein shuru kiya jaye to yeh sab se ziyada moassar hai. Rimantadine ko un afraad mein prophylaxis ke liye bhi istemaal kiya jata hai jinhen influenza A virus ke infection ka ziyada khatra hota hai, jaise ke sehat ki dekh bhaal karne walay karkunan, mutasir afraad ke ghareloo rabtay, aur taweel muddat ki nigrani ki saholiyat ke rehaishi.

Bura Asarath:

Rimantadine ke side effects mein maida ki alamat shamil hain, jaise matli, ultiyon aur pait mein dard. Dusre side effects mein chakkar aana, sir dard, bechaini aur uljhan shamil hain. Shadeed cases mein, Rimantadine sangeen aasabi zimni asrat ka sabab ban sakti hai, jaise dooray aur fareb. Ye asraat bozurg mareezon ya bunyadi aasabi halat ke hamil afrad mein zyada aam hain.

Tazad:

Rimantadine un mareezon mein mutazad hai jin ki dawai ya is ke ajza mein se kisi ke liye intehai hasasiat ki tareekh hai. Ye shadeed gurdon ki kharabi (creatinine clearance <10 milliliter/min) wale mareezon aur faal ya halia nafsiyati awariz wale mareezon mein bhi mutazad hai.

Manshiyat ka taamul:

Rimantadine dosri dawayon ke saath taamul kar sakti hai jo CYP2C9 aur CYP3A4 enzymes jaise warfarin aur erythromycin ke zariye metabolize hoti hain. Rimantadine in dawayon ke serum mein irtikab ko barha sakti hai, jis se khoon behne ka khatra barh jata hai (warfarin ke saath) ya zehreela (erythromycin ke saath). Rimantadine antacids aur dusri dawayon ke saath bhi taamul kar sakti hai jo maida ke pH ko barhati hain, Rimantadine ke jazb ko kam karti hain aur is ki afadiyat ko kam karti hain.