Co-trimoxazole | Drugs | BNF | NICE by-The Medicine Library

Cotrimoxazol:

Amal ka tareeqa kar:

Cotrimoxazole do antibiotics ka majmua hai - sulfamethoxazole aur trimethoprim. Ye bacterial folate ki formation ko rok kar kaam karta hai, jo nucleic acid aur protein ki tayyari ke liye zaroori hai. Aisa karne se, ye bacteria ki afzaish aur tayyari ko rokta hai.

Dawasazi:

Cotrimoxazole zubani intizamiya ke baad tezi se jazb hota hai aur jism ke bafaton mein wasee paimane par taqseem hota hai. Choti plasma ki satah 1-4 ghantay ke andar pohanch jati hai. Ye bunyadi tor par gardon ke zariye kharij hota hai.

Spectrum:

Cotrimoxazole mein gram positive aur gram negative dono bacteria ke khilaf sargarmi ka aik wasee medan hai, jis mein staphylococcus aureus, streptococcus pneumonia, escherichia coli, aur salmonella spp ke kuch tanao shamil hain.

Tibbi istemaal:

Cotrimoxazole mukhtalif qisam ke bacterial infections ke ilaj ke liye istemaal kiya jata hai, jaise peshab ki nali ke infection, sans ki nali ke infection, maiday ke infection, aur jild aur naram bafaton ke infection. Ye immunocompromised mareezon mein Pneumocystis jirovecii pneumonia ki rok tham aur ilaj ke liye bhi istemaal hota hai.

Bure asraat:

Cotrimoxazole ke aam manfi asraat mein matli, ulte, ishaal, aur jild par khushki shaamil hain. Naiyyab lekin sangeen manfi asraat mein khoon ki kharabi, jigar aur gurde ka nuqsaan, aur shadeed allergy ka rad-e-amal shaamil hain.

Tazadudat:

 Cotrimoxazole un mareezon mein mutazad hai jin mein sulphonamide ki intehai hissasati ya trimethoprim ki intehai hissasati ki tareekh hai. Hamila khawateen mein bhi is se parhez karna chahiye, khaas tor par pehli teen mahino mein.

Manshiyat ka ta'amul: 

Cotrimoxazole doosri dawayon jaise warfarin, phenytoin aur methotrexate ke saath ta'amul kar sakta hai, jo khoon behne, zehreela pan aur muzir asraat ka khatra barha sakta hai.

Nateeja:

 Cotrimoxazole aik mawaseer antibiotic hai jis mein mukhtalif bacterial infections ke khilaf wasee pemanay par sargarmi hai. Taham, usey baaz mareezon ki abadi mein ihtiyaat ke saath istemaal karna chahiye, aur us ke mumkin manfi asraat aur manshiyat ke ta'amulat ki ehtiyat se nigrani ki jani chahiye.