Antifungals, systemic use | Treatment summaries | BNF | NICE by-Medicine Library

Antifungal drug:

Fungal infection ke ilaj ke liye istemaal hone wali dawaiyon ko antifungal dawa kaha jata hai. Antifungal do tariko se kaam karte hain, woh fungus cell ko barah-e-raast maar dete hain ya unki nashonuma mein rehtey hain.

Antifungal dawai zubani tor par ya topical ya IV dey sakti hai jo infection par munhasar hai. Fungi poori duniya mein mukhtalif mahool mein paye jatey hain. Fungus mein se kuch logon mein fungal infection ka sabab nahin ban saktey hain jab ke fungi ki kuch parjatiyon se insanon mein kharabi paida hoti hai. Yeh fungus cell ki saakht ya function ke khilaf larhta hai jo fungal cell ke liye ahem hai. Woh fungal infection ke khilaf larhtey hain lekin insani jism ke khaliyon ko mutasir nahin karte hain.

Fungal infection:

Infection ki mukhtalif aqsam hain jaise keel, jild aur balgham ki jhilli. Mislain hain;

Daad: Isay tinea bhi kaha jata hai. Yeh jild ka fungal infection hai jo khopri, paon, nali ke ilaqey aur jism ke digar hisson par hota hai.

Keel fungus: Yeh aam tor par pair ke nakhuno ko mutasir karta hai aur nakhuno ko bhi mutasir kar sakta hai.Andam-e-nahani khamir ka infection: Yeh andam-e-nahani ke ander aur uske aas paas Candida khamir ki zyada nashonuma ki wajah se hota hai.

Zubani thrush: Yeh woh haalat hai jab Candida ka khamir munh mein zyada barh jata hai.

Classification:

Antifungal dawai ko darj zail aqsam mein darja kiya gaya hai.

• Polyened

• Allylamine

• Azoles

• Echinocandins

• Diger

Polyenes	Allylamine	Azole	Echinocandins	Others
Amphotericin-B Nystatin Natamycin	Naftifin Terbinafine Butanefine Tolnaflte	Imidazol Triazol Topical: Clotrinazole Econazole Miconazole Oxionazole Systemic: Ketoconazole Fluconazole Itraconazole Voriconazole Posaconazole	Capsofungin Micafungin Anidulafungin	Flucytocine Griscofulvin Tolnaflate Ciclopirox

Mechanism of action:

Aam tor par, anti-fungal manshiyat ke istemaal ka tareeqa kar bunyadi tor par seel ki jhilli mein khullam khulla karna hota hai. Fungal seel jhilli mein ek munfarid juz hota hai jo aam tor par anti-fungal dawayon ka hadaf hota hai, khaas tor par ergosterol mein. Yeh sterol hai jo munasib jhilli ke seyal aur seel jhilli ke aam kaam ko barqarar rakhne ke liye zaroori hai.