Piperacillin: Uses, Interactions, Mechanism of Action , Pharmacokinetics by-The Medicine Library

Piperacillin:

Taruf:

Piperacillin aik neem-musannif pencilin moshavvar hai jo pehli baar 1970 ki dahe'ee mein muta'arif kraya gaya tha. Yeh aik β-lactam anti-biotic hai jo bacterial cell wall ki tarteeb ko rok kar kaam karta hai, jis se yeh bacterial infection ki aik wasee rang ka moassar ilaaj hai. Piperacillin ko aksar β-lactamase inhibitor ke saath milaya jata hai jise tazobactam kehte hain takay β-lactamase paida karne wale bacteria ke khilaf is ki taseer ko barhaya ja sake.

Amal ka tareeqa kar:

Piperacillin bacterial cell ki deewar ki tarteeb mein mudaakhilat karke apne anti-bacterial asraat murattab karta hai. Yeh enzyme transpeptidases se munasalik aur rokta hai, jise pencilin binding proteins (PBPs) bhi kehte hain. PBPs bacterial cell wall mein peptidoglycan chains ko aapas mein jorne mein ahem kirdar ada karte hain, sakhti-salami faraham karte hain. PBPs ko rok kar, piperacillin bacterial cell wall ki tashkeel mein khalal dalta hai, jis se cell lysis aur maut hoti hai.

Dawasazi:

Piperacillin is ki naqis zabani geo dastiyabi ki wajah se nas ke zariye di jati hai. Yeh jism ke mukhtalif tissues aur fluids mein tezi se taqseem hota hai, bishmol saans ki naali, peshab, path, aur dimaghi spinal fluid mein. Piperacillin ki nisbatan mukhtasir nisf-zindagi taqreeban 30 minute se 1 ghante tak hoti hai. Yeh buniyadi tor par gurdey ke ikhraaj ke zariye kharij hota hai, aur gurdon ki kharabi wale mareezon mein khurak ki adjustmint zaroori hai.

Spectrum aur istemaal:

Piperacillin mein gram musbat aur gram manfi dono bacteria ke khilaf sargarmi ka aik wasee medaan hai. Yeh khaas tor par Enterobacteriaceae, Pseudomonas aeruginosa, aur bohat se anaerobic bacteria ke khilaf moassar hai. Lihaza, yeh aam tor par shadeed infection ke ilaj mein istemaal hota hai jaise ke intra-abdominal infection, pneumonia, peshab ki naali ke infection, jild aur narm bafton ke infection, aur hasas hayatiyat ki wajah se hone wale sepsis.

Manshiyat ka ta'amul:

Piperacillin doosre adwiyaat ke saath ta'amul kar sakti hai, aur mahfooz aur muzaffar ilaaj ko yaqeeni banane ke liye in ta'amulat se aagah hona zaroori hai. Doosre anti-biotics ke saath Piperacillin ka simultaneous istemaal, jin ke amal ka ek hi tareeqa kaar hai, jaise ke doosre penicillin ya cephalosporins, mukhalif asraat ka baais ban sakte hain. Probenecid ke saath Piperacillin ka beek waqt istemaal, gout ke ilaj ke liye istemaal honay wali dawa, is ke gurdon ke ikhraaj ko kam karke Piperacillin ki satah ko barha sakti hai. Sehat ki dekhbhaal karne walay peshawar se mashwara karna ya manshiyat ke ta'amulat ki mukammal fehrist ke liye tajweez karda maloomat ka hawala dena bohat zaroori hai.

Muzir asraat:

Kisi bhi dawa ki tarah, Piperacillin mumkinah zameeni asraat se wabasta hai. Sab se aam manfi rad-e-amal mein made ki kharabi jaise matli, ulte aur ishaal shamil hain. Allergic reaction bhi ho sakta hai, halkay dane se le kar shadeed intehai hasasat ke rad-e-amal jaise enfliksis tak. Mazeed bara, Piperacillin microbial flora ke mamooli tawazon mein khallal daal sakta hai, jis se thanvi infection jaise ke Clostridium difficile se wabasta ishaal ho sakta hai. Kisi bhi manfi asraat ke liye mareezon ki qareeb se nigraani karna aur agar zaroori ho toh dawa band karna zaroori hai.

Natija:

Piperacillin mukhtalif bacterial infections ke intizam mein ek qeemati anti-biotic hai. Is ka amal ka tareeqa kar, sargarmi ka wasee daaira, aur β-lactamase inhibitor ke saath milaap ise ilaaj ka ek moassir ikhtiyar banata hai. Tahaam, kisi bhi dawai ki tarah, mahfooz aur munasib istemaal ko yaqeeni banane ke liye is ke pharmacokinetics, mumkinah dawaiyon ke ta'amulat aur zameeni asraat par ghaur karna zaroori hai.