Pharmacokinetics of the penicillins -by-The Medicine Library

Pharmacokinetics of Penicillin:

Penicillin ke pharmacokinetics mein darj zeel iqdamat ki pehroei ki jati hai:

• Jazb

• Metabolism

• Ikhraj

• Intizamiya

• Intizamiya ka khatma

Jazb:

Zubani tor par di jani wali penicillin ka jazb is lehaz se mukhtalif hota hai;

Tezab istehkam

Protein binding

Nafcillin zubani intizamiya ke liye muzoon nahi hai kyun ke is ka mede mein jazb be tarteeb hai.

Beta lactam antibiotics jism mein achi tarah se taqseem ho kar, naal ki rukaawat ko paar kar ke pooray jism mein phel jatay hain. 

Metablosim:

Beta lactam antibiotics ka host metabolism ahem nahi hai, lekin Penicillin G ka kuch metabolism kharaab gurdon ke faal wale mareezon mein paya jata hai.

Akhrāj:

Akhrāj kā bunyādī rāstah nali n'mā nizām hai jaise keh garday aur glomērolar filtration. Pensilin kī kuchh dawayen jaise nefslin, dikloksasilen aur aksasilen iss qā'ide se mustasna hain aur garday se khārij nahīn hotīn.

Yeh chhaati ke doodh mein bhī khārij hosakta hai.

Intizāmiyah:

Iss kā tayyin daway ke gastrik asid mein istehkām aur infection kī shiddat se hotā hai.

Intizāmiyah kā rāstah:

Ticarcillin, piperacillin aur ampicillin kā combination sulbactam ke sāth, ticarcillin with clavulanic acid, aur piperacillin ko tazobactam ke sāth intravenously yā intramuscular mein diyā jānā chāhiye.

Penicillin V, amoxicillin aur amoxicillin ko clavulanic acid ke sāth milā kar sirf zabāni tayyāri ke taur par dastiyāb hain.