Cycloserine-Uses, Interactions, Mechanism of Action, Pharmacokinetics, Side effects by-The Medicine Library

 Cycloserine:

Taruf: 

 Cycloserine aik anti-biotic hai jo bunyadi tor par tap daq ke ilaj mein istemaal hoti hai. Yeh amino acid D-alanine ka aik sakhti yaanalaag hai aur bacteria mein cell wall peptidoglycan ke biosynthesis ke liye zimmedar enzymes ko rok kar kaam karta hai. Is ki anti-bacterial khosusiyaat ke ilawa, cycloserine ko aztaarab ke awaared ke ilaj aur ilmi izafay ke tor par bhi istemaal kya gaya hai.

Amal ka tareqa:

Saiklooserin bacterial cell wall ka aik ahem juz peptidoglycan ke biosynthesis mein shamil enzymes ko rok kar kaam karta hai. Khaas tor par, yeh do khamron, D-alanine racemase aur D-alanine ligase ko rokta hai, jo D-alanine ki tarkib mein shamil hain, jo peptidoglycan ka aik lazmi juz hai.

Dawsazi:

Saiklosireen maiday ki naali se achi tarah jazb hoti hai, aur zubani istemaal ke 2 ghanton ke andar serum ki zyada miqdar hoti hai. Manshiyat bunyadi tor par jigar ke zariye metabolize hoti hai aur peshab mein kharij hoti hai, jis ki nisf zindagi taqreeban 10 ghanton hai.

Spektrum: 

Saiklosireen bacteria ki aik wasi range ke khilaf sar garam hai, beshumaar miko-bacteria ke sath sath gram musbat aur gram manfi hayatiyat.

Estimal karna ka tareqa:

Cycle-serene buniyadi tor par tap daq ke ilaj mein istemaal hoti hai, khas tor par manshiyat se muzahim bemari ke mamlaat mein. Yah aksar dosri dawayon ke sath mil kar istemaal kia jata hai, jaise ke refampin aur aisoniazid. TB mein is ke istemaal ke ilawa, cycle-serene ko aztaab ki kharabi ke ilaj mein bhi istemaal kia gaya hai, jaise ke samaji phobia aur junooni majboori ki kharabi. Is ka mutalea ilmi izafa ke tor par bhi kia gaya hai, khas tor par Alzheimer ki bemari ke ilaj mein.

Manshiyat ka taamul: 

Cycle-serene kayi dosri dawayon ke sath taamul kar sakti hai, bishmol antacids, aisoniazid, aur phenobarbital. Antacids cycle-serene ke jazb ko kam kar sakte hain, jabke aisoniazid si-enss zehreela honay ka khatra barhha sakta hai. Phenobarbital cycle-serene ke metabolism ko barhha sakta hai, is ki taseer ko kam kar sakte hain.

Muzir asraat:

 Sikloserin ke sab se aam zamni asraat mein CNS ka zehreela pan shamil hain, jaise uljhann, chakkar aana, aur dore. Digar kam aam zamni asraat mein peiriferl neuropathy, hepatotoxicity, aur hematological asamaniyat shamil hain. Gardon ki kharabi ya dorey wale afraad mein CNS zehreela honay ka khatra barh jata hai.

Nateeja: 

Sikloserin tapdaq ke ilaj mein aik ahem dawa hai, khas tor par manshiyat se muzahim bemari ke mamlat mein. Is ka amal ka tareeqa-e-kar munfarid hai, aur yeh bacteria ki aik wasiyaa range ke khilaaf sar-garm hai. Taham, yeh ahem zamni asraat ka sabab ban sakta hai, khas tor par CNS zehreela, jis ka intezam mareezon ki qareebi nigrani se kia ja sakta hai. Iztarab ki kharabiyon ke ilaj aur ilmi izafa mein is ke istemaal ka abhi bhi mutalia kia ja raha hai, aur in ilaqon mein is ki ifadat ka taeen karnay ke liye mazeed tehqeeq ki zaroorat hai. Mujamalat tor par, Sikloserin tapdaq ke ilaj ke liye ghiza ka aik ahem juzo bani hui hai, aur is ka istemaal mustaqbil qareeb tak jari rehne ka imkaan hai.