Azole drug -Antifungals- | uses-pharmacokinetics-side effect-by The Medicine Library

Azole drug:

Taruf:

Yeh anti-fungal dawa hai aur is mein azole ki ungli hoti hai. Yeh fungus ki nashonuma mein rehta hai. Azole jo systemic ke liye dastiyab hain ko 2 groups mein taqseem kiya gaya hai.

• Triazole:

(fluconazole, itrakonazole, voriconazole, posaconazole, isavuconazole)

• Imidazole:

(ketoconazole)

Azole ka istemal jism aur jild ke fungal infections jaise k khilaadiyon ke paon, onychomycosis, daad aur andam nihani candidiasis ke ilaj ke liye kiya jata hai.

Tijarati naam:

Azole

Dastiyab: 

Rx aur/ya OTC

Aam Omiprazole

Omiprazole dosray naam OMEP, Omiprazole, Omiprazolem

Wazan: 

200mg/5ml, 400mg

Qisam:

 Capsule, Zabani Matli, Goli

Formula:

 C17H19N3O3S

Ausaat wazan:

 345.416

Protein binding taqriban 95% insani plasma protein se juri hui hai.

Groups manzoor shuda, tafteeshi, vet ki manzoori di gayi hai.

Elaj ki class:

 Proton pump rokne wala

Spectrum:

Azole dawai ki sargarmi ka wasee meidan hai. Yeh khilaf sargarmi zahir karta hai:

• Aspergillus

• Histoplasma

• Coccidioides

• Dermatophytes

• Cryptococcus

• Mucormycosis

• Blastomycosis

Tibbi istemaal:

Ye androni tor par amphotericin muzahimi hayatiyat ke ilaj mein istemaal hota hai. Ye jild aur systemic mucococcus ke prophylaxis ke ilaj ke liye pehli line dawai ke tor par istemaal hota hai. Ye jism aur jild ke fungal infection ke ilaj ke liye bhi istemaal hota hai. Azole andam nahani candidiasis aur dad ke ilaj ke liye bhi istemaal hota hai. Ye jild ke infection ke liye bhi istemaal hota hai.

Manfi asar:

Itraconazole ke taweel muddati istemaal ka sabab ban sakta hai.

Hepatotoxicity aur hormone se mutaliq asraat

• Gynaecomastia samait

• Alopecia

• Libido mein kami

• Oligospermia

• Azoospermia

• Namardi

• Hypokalaemia

Hyponatremia, aur (shaaz o naadir hi) adrenal ki kami

• Mamooli GI pareshan

• Jigar ke enzymes mein izafa karein.

• Hepatitis (shaaz o naadir hi)