Digoxin Uses, Dosage & Side Effects - Drugs.com by-The Medicine Library

Digoxin:

Tarruf:

Digoxin aik cardiac glycoside dawa hai jo dil ki nakami aur atrial fibrillation ke ilaj ke liye istemaal hoti hai. Yah aik qudrati murakkab hai jo foxglove ke patton se hasil hota hai. Isay pehli baar 18veen sadi mein dawaaon ke tour par istemaal kya gaya tha, aur tab se yeh dil ki mukhtalif halatoun ke ilaj ke liye bade paimane par istemaal hota raha hai. Is maudoo mein, hum digoxin ke amal ke tareeqa kar, pharmacokinetics, spectrum, tibbi istemaal, manfi asraat, tadadadat, manshiyat ke ta'amulat par tabadla-e-khayal karenge aur dawa ke mukhtasar khulase ke sath ikhtitam karenge.

Amal ka tareeqa:

 Digoxin cardiac sales mein sodium-potassium ATPase pump ko rok kar kaam karta hai, jo intracellular calcium ki tadad mein izafay ka baais banata hai. Calcium ke irtikaz mein yeh izafa qalbi sukrao ko barhata hai aur dil ki dhadkan ko kam karta hai, is tarah cardiac function ko behtar banata hai. Is ke ilawah, digoxin ke atrioventricular (AV) node par bhi barah-e-raast asarat partay hain, transmission ki raftaar ko kam karte hain aur refractory muddat ko toul dete hain.

Dawasazi: 

Digoxin zubani tor par achi tarah jazb hota hai, jiski hayatiati dastiyabi taqreeban 70% hai. Zubani intizamiya ke 1-3 ghantay baad plasma ki ziyada miqdar hoti hai. Manshiyat ki nisf zindagi taqreeban 36 ghantay hai, jo girdon ki kharabi ke mareezon mein taweel hosakti hai. Yeh buniyadi tor par girdon ke akhraj ke zariye kharij hota hai, jiska ek chhota sa hissa biliary akhraj ke zariye kharij hota hai.

Spectrum: 

Digoxin buniyadi tor par dil ki nakami aur atrial fibrillation ke ilaj mein istemaal hota hai. Yeh ventricular arrhythmias ke ilaj ke liye moassir nahi hai.

Tibbi istemal:

Digoxin dil ki nakami ke ilaj ke liye kam ejection fraction (HFrEF) aur atrial fibrillation (AF) ke sath ishara kiya jata hai. Yeh halkay se itidal pasand dil ki nakami ke mareezon mein istemaal hota hai, khas tor par woh log jo dosray ilaj ke liye jawabdeh nahin hain. AF ke mareezon mein, digoxin ko dil ki dhadkan ko control karne aur alamat ko behtar banana ke liye istemaal kiya ja sakta hai.

Bura asraat:

Bure asraat mein, digoxin se wabasta sab se aam manfi asraat mein maida ki kharabi (matli, uliti, ishaal), basri khilal (dhundla pan, zard saabz nazar), aur cardiac arrhythmia (khas tor par hypokalemia ke mareezon mein) shamil hain. Zehreela pan bhi ho sakta hai, khas tor par un mareezon mein jo gurdun ki kharabi ka shikar hain ya jo dosri dawayen le rahe hain jo digoxin ke sath taamul kar sakti hain.

Tazadat:

Tazadat mein, ventricular arrhythmias ke sath mareezon mein Digoxin contraindicated hai, kyunke yeh un haalaat ko barhha sakta hai. Gurdun ki kharabi ya electrolyte adam tawazun wale mareezon mein bhi isay ehtiyat ke sath istemaal kiya jana chahiye.

Manshiyat ka taamul:

 Digoxin mutadid dawayon ke sath taamul kar sakta hai, beshumar diuretics, calcium channel blockers, aur beta blockers. Yeh taamul digoxin ke pharmacokinetics ko tabdeel kar sakte hain aur zehreela honay ka khatra barha sakte hain.

Natija: 

Digoxin aik cardiac glycoside dawa hai jo buniyadi tor par dil ki nakami aur atrial fibrillation ke ilaj mein istemaal hoti hai. Yeh cardiac cells mein sodium-potassium ATPase pump ko rok kar kaam karta hai, jis se intracellular calcium ki tadaad mein izafah hota hai. Digoxin aik taweel nisf zindagi hai aur buniyadi tor par gurdoun ke ikhraaj ke zariye khatam kiya jata hai. Digoxin ke sath mansalik manfi asraat mein maaday ki kharabi, bursi khallal, aur cardiac arrhythmia shamil hain. Yeh ventricular arrhythmia ke mareezon mein mutazad hai aur gurdoun ki kharabi ya electrolyte adam-e-tawazun wale mareezon mein ehtiyaat ke sath istemaal kiya jana chahiye. Dawaiyon ka ta'amul digoxin ke pharmacokinetics ko badal sakta hai aur zehreela hone ka khatra barh sakta hai.