Bedaquiline | Drugs | BNF | NICE by-Medicine Library

Bedaquiline:

Tarruf:

Yeh third line anti-tubercular dawayen hai. Iss mein naql tayyar karne wale aur ghair naql karne wale baseley dono ke khilaf inivtro sargarmi hai. Iss mein jaraseem kash sargarmi aur jaraseem kash sargarmi bhi hoti hai. Yeh anti-biotic hai jo TB ke ilaj ke liye dosri dawayon ke sath istemaal hoti hai jo aam tor par multi-drug resistance TB ka ilaj karti hai. Bedakulin jaraseem kash ke tor par kaam karti hai.

Formula:

Iss ka formula C₃₂H₃₁BrN₂O hai.

Tijarti naam:

Iss ka tijarti naam Sirturo hai.

Amal ka tareeqa kar:

Yeh ATP synthesis ke liye proton pump ko abad karta hai, iss ki wajah se ATP ki tashkeel ruk jati hai aur mycobacteria ki nashonuma ko rokti hai aur khilayon ki maut waqai hoti hai.

Dawasazi:

Yeh zubani tor par istemal kya jata hai aur achhi tarah jazb hota hai aur pure jism mein achhi tarah se taqseem hota hai. Chicken wale khanay ke sath iss ka jazb barh jata hai aur plasma protein binding 99% hota hai. Bedakulin ki nisf zindagi 5.5 mah hai. Yeh jigar ke zariye metabolize hota hai aur mal ke zariye kharij hota hai.

Tibbi istemaal:

Pulmonary multi-drug resistant TB ke saath balghon mein majmu'a therapy ke aik hissay ke tor par. Yeh phaiphron aur jism ke doosray hisson ko mutasir karne wale sangin infection mein bhi moassar hai. Yeh tapdaq ke liye bhi istemaal hota hai.

Manfi asar:

Aham zamni asar matli, joron ka dard, seenay mein dard, aur sar dard hai. Digar manfi asraat cardio-toxicity, hepatotoxicity, QTC length aur cardiac asamnita hain.

Mutazad:

Calcium, magnesium aur potassium ki kami walay mareezon mein mutazad hai.