Cefditoren: Mechanism of Action, Pharmacokinetics, Uses, Side Effects by-The Medicine Library

 Cefditoren:

Cefditoren ek teesri nasal ka sephalosporin antibiotic hai jo bacteria ki ek wide range ke khilaf wide spectrum sargarmi ko zahir karta hai. Yeh aam tor par mukhtalif bacterial infections ke ilaj ke liye tajweez kiya jata hai, beshumar infections mein se includinng saans ki nali ke infection, jild aur naram tissue ke infection, aur peshab ki nali ke infection. Cefditoren ki afadiyat, hifazati profile, aur pharmacokinetic khasosiyat ise antimicrobial agents ke hathiyaron mein ek qeemti option banati hain. Is jayeze mein, hum amal ke tareeqe, pharmacokinetics, sargarmi ke spectrum, tibi istemal, munsheyat ke tamalat, aur cefditoren ke mumkinah zimni asrat ka jayeza lenge.

Amal ka tareeqa:

Cefditoren bacterial cell wall ki tarkeebi rok tham ke zariye apne antimicrobial asrat murtab karta hai. Dusre sephalosporins ki tarah, cefditoren penicillin binding proteins (PBPs) se mansalik hota hai, khas tor par PBP-3, jo transpeptidation aur khaley ki deewaron ko aapas mein jorne ke amal mein khillat ka banta hai. Is ke natijay mein asamotik adam istehkam aur lysis ki wajah se bacterial cell ki maut waqe hoti hai.

Dawasazi:

Zubani istemal ke baad, cefditoren made se tezi se jazb ho jata hai. Khurak ki maujoodgi is ke jazb mein takheer karti hai, lekin yeh jazb ki had ko numaya tor par mutasir nahi karta hai. Cefditoren achi jeo dastiyabu ka muzahira karta hai, 2-3 ghante ke andar plasma ki buland tareen satah tak pohanch jata hai. Munsheyat ko baray pemanay par jism ke tamam tissues aur salyon mein taqseem kiya jata hai, includinng saans ki nali, jild aur peshab ki nali. Cefditoren ek nisbatan taweel nisf zindagi ki numayaish karta hai, jo rozana ek ya do baar khurak lenay ke tareeqe ke ijazat deta hai.

Sargarmi ka spectrum:

Cefditoren gram musbat aur gram manfi dono bacteria ke khilaf sargarmi ke ek wide field ki numayaish karta hai. Yeh khas tor par aam saans ke pathogens ke khilaf mufeed hai, includinng Streptococcus pneumoniae, Haemophilus influenzae, aur Moraxella catarrhalis. Mazeed baran, cefditoren Staphylococcus aureus ke mukhtalif tanau ke khilaf sargarmi ka muzahira karta hai, dono methicillin hasas aur methicillin muzahim.

Cefditoren istemal:

Cefditoren mukhtalif bacterial infections ke ilaj mein afadiyat talash karta hai, bishmol community se hasil shuda sans ki nali ke infections jaise ke acute otitis media, mazboot bronchitis ki shadeed shiddat, aur community se hasil shuda pneumonia. Yah ghair picheda jild aur jild ki sakht ke infections ke liye bhi ishara kiya jata hai, bishmol cellulitis aur impetigo. Mazeed baran, Cefditoren ko hasas janwaron ki wajah se peshab ki nali ke ghair picheda infection ke ilaj ke liye manzoor kiya jata hai.

Manshiyat ke taamulat:

Cefditoren, digar cephalosporins ki tarah, aam tor par manshiyat ke ahem taamul ki kam salahiyat ko zahir karta hai. Yah cytochrome P450 enzymes ko rokta ya unki hawsala afzai nahi karta, is tarah digar adwiyaat ke saath metabolism taamul ke khatre ko kam karta hai. Tahaam, Cefditoren ko dawaiyon ke saath mil kar istemal karte waqt ihtiyat bartani chahiye jo gurdon ke kaam ko mutasir kar sakti hain, kyunke ek saath istemal karne se nephrotoxicity ka khatra barh sakta hai.

Muzir Asarat:

Cefditoren ke sab se zyada aam tor par riport honay walay zimni asarat mein maida ki kharabi jaise ishaal, matli, aur pait mein dard shamil hain. Digar manfi rad-e-amal mein sir dard, chakkar aana, dawra, aur allergik rad-e-amal shamil ho sakte hain jin mein jild ke halkay dhabay se le kar shadeed hasasiyat ke rad-e-amal tak shamil hain. Cefditoren ke istemal ke saath Clostridioides difficile se wabasta ishaal ki bhi etlaa di gayi hai, agar bhi kabhi kabhaar.