YOHIMBE... Mechanism of Action, Pharmacokinetics, Uses, Side Effects by-The Medicine Library

Yohimbine:

Taruf:

Yohimbine ek alcoholide hai jo Afriqi darakht Pausinystalia yohimbe ki chhaal se makhzuud hota hai. Yeh sadiyon se rawaayati adwiyaat mein Afrodisiak, uzoo tanasul ke ilaj aur mharik ke tor par istemaal hota raha hai. Yohimbine ka is ke pharmacological khasosiat ke liye bara paimane par mutalea kya gaya hai, jis mein is ke amal ka tareeqa kar, pharmaco-kinetics, tibi istemal, manfi asraat, tazadud aur manshiyat ke talluq shamil hain.

Amal ka tareeqa kar:

Yohimbine alpha-2 adrenergic receptors ka mukhalif hai, jo buniyadi tor par markazi aur purdii asabi nizaam mein waqei hain. In receptors ko masdoom karke, yohimbine norepinephrine aur dopamine ke ikhraaj ko barhata hai, jo ke neurotransmitters hain jo mood, hosla afzai aur jinsi fail ko muntazam karne mein kirdar ada karte hain. Yohimbine norepinephrine aur dopamine ke dobarah istemaal ko bhi rokta hai, in ke asraat ko mazeed barhata hai.

Dawasazi:

Yohimbine zubani intizamiya ke baad tezi se jazb hota hai, plasma mein 1-2 ghanton ke andar andar sub se ziyada irtaqa hota hai. Is ki nisf zindagi taqreeban 2.5 ghante hoti hai aur yeh buniyadi tor par jigar mein metabolism hoti hai. Metabolites peshab mein kharij hote hain, 1% se bhi kam ikhraaj mein koi tabdeeli nahi hoti.

Spectrum:

Yohimbine ko mukhtalif qisam ke haalaat ke ilaj ke liye istemaal kiya gaya hai, bishmoal uzoo tanasul, jinsi kamzori, depression, izteraab aur motapa. Post traumatic stress disorder (PTSD) ke ilaj ke tor par aur psychotherapy ke sath mansalik ke tor par is ki salahiyat ke liye bhi is ka mutalea kya gaya hai.

Tibbi istemaal:

Azoo-e-tanasul ki kharabi: Yohimbein ko 1930 ki dahai se azoo-e-tanasul ke ilaj ke taur par istemaal kiya jata hai. Yeh azoo-e-tanasul mein khoon ke behaao ko barhaakar aur jinsi josh mein shamil neurotransmitter ki rehai ko barhaakar azoo-e-tanasul ke af’aal ko behtar banane ke bare mein socha jata hai.

Jinsi kharabi: 

Yohimbein ko khawateen mein jinsi kamzori ke ilaj ke taur par bhi mutalia kiya gaya hai, beshumaar haipo-ekto jinsi khwahish ki kharabi (HSDD) aur jinsi hawas afzaai ki kharabi, shamil hain. Mutaleaat ne mily-july natayej dikhaay hain, jin mein se kuch jinsi fail mein mamooli behtari ki nishandehi karte hain aur doosron ne koi khaas faida nahin dikhaya.

Depression aur iztarab:

 Yohimbein ka mutalea depression ke khilaf muzahimat ke liye rawa’iti anti-depressant therapy se mansalik ke taur par kiya gaya hai. Is ke iztarabi asraat bhi dikhaaye gaye hain, jo kuch afraad mein iztarab ki alamat ko kam karte hain.

Motapa: 

Yohimbein ka mutalea motape ke mumkinah ilaj ke taur par kiya gaya hai, kyun keh yeh socha jata hai keh yeh tawanai ke akhrajat ko barhata hai aur khane ki miqdaar ko kam karta hai. Tahaum, is ki ifaadiyat ke saboot mehdood hain aur mazeed tehqeeq ki zaroorat hai.

Post-traumatic stress disorder:

 Yohimbein ka mutalea PTSD ke mumkinah ilaj ke taur par kiya gaya hai, khaas tour par exposure therapy ke saath. Natayej mily-july hain, kuch mutaleaat ke saath alamat mein kami aur doosre koi khaas faida nahin dikharahe hain.

Yohimbine kay bure asrat:

Yohimbine mukhtalif qism kay manfi asrat ka sabab ban sakta hai, beshumar masail mein dil ki sharah mein izafah, blood pressure, aur bay cheeni. Yeh maday ki takleef, bay khawabi aur sar dard ka bhi sabab ban sakta hai. Shadeed aur nadir soraton mein, yeh zyada sangeen manfi asrat ka sabab ban sakta hai, jaise dorahe aur fareb.

Tazadat:

Yohimbine unn afrad mein mutazad hai jo dil ki bimari, high blood pressure ya gurdy ki bimari ki tarikh rakhte hain. Blood pressure ko mutasir karne wali dawayen lenay wale afrad mein bhi iss se parhaiz kiya jana chahiye, kyunkeh yeh khatarnak taa'mul ka sabab ban sakta hai. Yohimbine ko anti-depressant adwiyaat kay sath nahi lena chahiye, kyunkeh yeh serotonin syndrome ka khatrah barha sakta hai.

Manshiyat ka ta'amul:

Yohimbine mutadid adwiyaat kay sath ta'amul kar sakti hai, beshumar masail mein antidepressants, antihypertensive adwiyaat, aur stimulants. Issay monoamine oxidase inhibitors (MAOIs) kay sath nahi lena chahiye, kyunkeh yeh blood pressure mein khatarnak izafay ka sabab ban sakta hai.