Terbinafine: Uses, drug Interactions, Mechanism of Action - pharmacokinetis, ADRs by-The Medicine Library

Terbinafine:

Taruf:

Terbinafine ek maflooj ilaamai fungal agent hai jo aam tor par jild, baalon aur nakhoono ke surface ki fungal infection ke ilaj ke liye istemaal hota hai. Yeh ek lipophilic dawa hai jo jild, baalon aur nakhoono mein jama hoti hai, jahan iska taweel ilaj ka asar hota hai. Terbinafine muntakhib tor par squalene epoxidase ko rokta hai, ek enzyme jo ergosterol ke biosynthesis mein shamil hai, jo fungal cell membranes ka ek lazmi juz hai. Is enzyme ko rok kar, terbinafine fungal cell ki membrane mein khallal daalta hai aur fungal cell ki maut ka sabab banta hai.

Amal ka tareqa:

Terbinafine squalene epoxidase ko rokta hai, aik enzyme jo ergosterol ke biosynthesis mein shamil hai, jo fungal cell membranes ka aik lazmi juz hai. Fungal cell membrane ki formation aur kaam ke liye ergosterol zaroori hai, aur Terbinafine ergosterol ki formation ko rok kar fungal cell membrane mein khala dalta hai. Is ke natije mein fungal cell ki maut hoti hai aur fungal infection ki clearance hoti hai.

Dawasazi:

 Zubani intizamiya ke baad Terbinafine tezi se jazb ho jata hai aur is ki hayatiati dastiyabi taqreeban 70% hoti hai. Yah dawa intehai lipophilic hai aur isay jild, baalon aur naakhuno mein bade paimane par taqseem kya jata hai, jahan is ka taweel ilaj mualja hota hai. Dawa jigar ke zariye bade paimane par metabolize hoti hai aur peshab aur pakhana mein kharij hoti hai. Terbinafine ke khatmay ki nisf zindagi taqreeban 36 ghante hai, jo rozana aik bar khoraak ki ijazat deti hai.

Spectrum: 

Terbinafine mein fungus ki ek range ke khilaf wasee spectrum sargarmi hai, beshumar dermatophytes, khamir aur sanche. Yah dawa khas tor par dermatophytes ke khilaf mawafiq hai, jo jild, baalon aur naakhuno ke satahi fungus infection ki sab se aam wajah hain.

Dawasazi:

Terbinafine aam tor par jild, baalon aur nakhuno ke surfacey fungal infection ke ilaj ke liye istemaal kiya jata hai, beshumar tibqat mein tinea corporis, tinea cruris, tinea pedis, aur onychomycosis shamil hain. Ye dawa pityriasis versicolor ke khilaf bhi kargar hai, jo Malassezia ki nasal ki wajah se jild ka ek fungal infection hai. Infection ki jagah aur shadeedat par munhasar hai, Terbinafine zubani tor par ya oopri tor par diya ja sakta hai.

Manshiyat ka ta'amul:

 Terbinafine jigar ke zariye metabolize hota hai aur doosri dawaiyon ke saath ta'amul kar sakta hai jo isi raastay se metabolize hote hain. Ye dawa warfarin, cyclosporine, aur trycyclic antidepressants jaisi dawaiyon ke plasma concentration ko barha sakti hai, jo manfi asraat ka khatra barha sakta hai. Terbinafine in dawaiyon ke saath bhi ta'amul kar sakta hai jo cytochrome P450 enzymes ko rokthi hain, jaise ke baltareen aur ketoconazole.

Ma'dar asrat: 

Terbinafine ke sab se aam zimni asrat mein mede ki alamat shamil hain, jaise matli, ultii, aur pait mein dard. Digar aam zimni asrat mein sar dard, chakkar aana aur khujli shamil hain. Nayab lekin sangeen zimni asrat mein hepatotoxicity, neutropenia, aur Stevens-Johnson syndrome shamil hain. Pehle se maujood jigar ki bimari ya jigar ki bimari ke khatre wale aumal wale mareezon ko hepatotoxicity ki alamat ke liye qareeb se monitor kiya jana chahiye.

Nateeja: 

Terbinafine aik masnoi ilailamain anti-fungal agent hai jo iskovaline epoxydases ko muntakhib tour par rokta hai, aik enzyme jo ergosterol ke biosynthesis mein shamil hai, jo fungal cell jhilliyon ka aik lazmi juz hai. Dawai mein fungi ki aik had ke khilaf wasia spectrum sargarmi hai aur yeh khas tour par dermatophytes ke khilaf muzir hai. Terbinafine zubani tour par ya oopri tour par diya ja sakta hai aur aam tour par jild, balon aur nakhhuno ke satahi fungal infection ke ilaj ke liye istemaal hota hai. Manshiyat ko aam tour par achhi tarah se bardasht kiya jata hai, lekin jigar ki bimari ya jigar ki bimari ke khatre wale aumal wale mareezon ko hepatotoxicity ki alamat ke liye qareeb se monitor kiya jana chahiye. Mujamli tour par, terbinafine ka istemaal fawaidmand hai.