Bisoprolol: Mechanism of Action, Pharmacokinetics, Spectrum, Side Effects, Uses by-The Medicine Library

Bisoprolol:

Tarruf:

 Bisoprolol ek beta-1 adrenergic receptor blocker hai jo dil ki kai tarah ke halat ke ilaj ke liye istemaal hota hai. Is ka market naam Bismolol hai. Ye ek safed, crystal powder hai jo pani mein asaani se hal ho jata hai aur is ka molecular weight 325.4 hai. Bisoprolol ko sab se pehle 1992 mein American Food and Drug Administration (FDA) ne high blood pressure ke ilaj ke liye manzoor kiya tha.

Amal ka tareka-kar:

Is ka tareeqa-e-kar yeh hai ke Bisoprolol dil mein beta-1 adrenergic receptors ko muntakhib tor par masdoor karke kaam karta hai, jo dil ki sunkan ki quwwat aur sharah ko kam karta hai. Is se blood pressure aur dil ki dhadkan mein kami paida hoti hai, jis se ye high blood pressure, angina aur dil ki nakami ka aik moaser ilaj hai. Dil ke kaam ka bojh kam karke, Bisoprolol seenay mein dard, saans ki kamzori aur thakan ki alamat ko behtar banane mein bhi madad kar sakta hai.

Dawasazi:

Zubani intizamiya ke baad Bisoprolol tezi se jazb ho jata hai, plasma mein 1-2 ghanton ke andar upper level par pohanch jata hai. Manshiyat jigar mein baray paimane par metabolize hoti hai aur bunyadi tour par peshab mein kharij hoti hai. Bisoprolol ke khatmay ki nisf zindagi taqreeban 10 ghante hai, aur ye aik ghair faa'al metabolite mein metabolize ho jata hai, jo peshab mein kharij hota hai.

Spectrum:

Bismolol bunyadi tor par high blood pressure ke ilaj ke liye istemaal hota hai, lekin yeh degar qalbi haalat jaise angina, dil ki kharabi, aur atrial fibrillation ke intizam mein bhi moaser hai. Yeh dil ki nakami ke mareezon mein khas tor par mufeed hai, kyunkay yeh alamat ko behtar banane aur hospital mein dakhil honay ko kam karne ke liye dikhaaya gaya hai.

Tibbi istemaal:

Bismolol ka istemaal dil ki mukhtalif haalton ke ilaj ke liye kya jaata hai, bishmool:

High blood pressure:

 Bismolol high blood pressure ka pehla ilaj hai aur isay akelay ya degar anti-hypertension agents ke saath mil kar istemaal kya ja sakta hai.

Angina: 

Bismolol angina ki alamat ko kam karne mein moaser hai, bishmool seenay mein dard, saans ki qillat aur thakawat.

Dil ki nakami:

Bismolol ko dil ki nakami ke mareezon mein alamat ko behtar banane aur hospital mein dakhil honay ko kam karne ke liye dikhaaya gaya hai.

Atrial fibrillation: 

Bismolol atrial fibrillation ke mareezon mein dil ki dhadkan ko control karne mein moaser hai.

Bura Asrath:

Bismolol ka aam tour par achhi tarah se bardasht kiya jata hai, lekin tamam adwiyaat ki tarah, yeh zimni asraat ka sabab ban sakta hai. Bismolol ke istemaal se wabasta sab se aam manfi asraat mein thakawat, chakkar aana, sar dard aur matli shamil hain. Yeh zimni asraat aam tour par halkay hote hain aur khud hi hal ho jate hain. Shaaz o naadir soraton mein, bismolol zyada sangin zimni asraat ka sabab ban sakta hai, jaise bronchospasm, hypotension, aur dil ki nakami.

Tazad: 

Bismolol un mareezon mein mutazad hai jin mein dawai ya is ke kisi bhi ajza ke bare mein maloom intehai hassasiyat hai. Isay damah, daemi rukawat pulmonary bemari (COPD) aur ziyabeteis ke mareezon mein bhi ehtiyat ke sath istemaal kiya jana chahiye, kiunkeh yeh in haalaat ko mazeed kharab kar sakta hai.

Manshiyat ka taawun:

Bismolol doosri dawaiyon ke saath taawun kar sakta hai, beshumaar khaas tor par calcium channel blockers, digoxin, aur insulin ke saath. Yeh dawaaien lene wale mareezon ko manshiyat ke taawun ki kisi bhi alamat jaise hypertension ya bradycardia ke liye qareeb se nigraani ki jaani chahiye.

Natija:

Bismolol high blood pressure, angina, dil ki nakami, aur atrial fibrillation ke ilaj ke liye ek moassar dawa hai. Yeh dil mein beta-1 adrenergic receptors ko muntakhab tor par block karke kaam karta hai, jo dil ke sukarnay ki quwwat aur sharah ko kam karta hai. Agarcha aam tor par achhi tarah se bardasht kiya jata hai, bismolol zimni asrat ka sabab ban sakta hai aur baaz mareezon ki aabaadi mein ehtiyaat ke saath istemaal kiya jana chahiye.